Clinical immunology Essay Example | Topics and Well Written Essays - 500 words

Clinical immunology - Essay Example n recipients of any organ transplant, in whom the prevalence of morbidities such as systemic hypertension, diabetes mellitus, renal insufficiency, and malignancy remain high as compared with the general population. The barriers to short and long-term success of transplant procedures are predominantly the result of incompatibility between donor and recipient, acute and chronic rejection, and complications of long-term pharmacologic immune suppression. This is the reason why clinicians need to consider several factors prior to transplantation. Examples of conditions to be studied include, but are not limited to: 6. Susceptibility to and prevention of the adverse consequences (e.g., nephropathy, systemic hypertension, diabetes mellitus, malignancy) of current post-transplant immunosuppressive regimens (Department of Health and Human Services, 2003). In many cases of transplantation the histocompatibility barrier between recipient and donor remains a problem in that it will activate immune responses leading to graft rejection. Because HLA plays such a dominant role in transplant immunity, pre-transplant histocompatibility testing seems important for organ transplantation. In order to appreciate the role of Human Leukocyte Antigen (HLA) in transplantation, we must first consider the structural and functional aspects of HLA molecules. HLA antigens are controlled by a series of highly polymorphic genes on the short arm of chromosome 6, referred to as the human MHC. These genes have been classified into major categories. HLA-A, HLA-B and HLA-C encode for Class I molecules consisting of a 45kD glycopeptide chain complexed to a 12kD ï  ¢2-microglobulin chain encoded by a nonpolymorphic gene on chromosome 15. The genes in the HLA-DR, HLA-DQ and HLA-DP regions encode for Class II molecules consisting of a ~30kD ï  ¡-chain and a ~28k D ï  ¢-chain. These HLA class I and class II alloantigens can induce transplant immunity at both humoral (antibody) and cellular (T lymphocyte)

ABSTRACT AND CONCLUSION for my critical communication event in recent Essay

ABSTRACT AND CONCLUSION for my critical communication event in recent history - Essay Example Critical communication encompasses several avenues, taking the simplest avenue at one point, and a complex one at another. These avenues include: the press, film, radio, television, internet and wireless communication. This paper will focus on individual critical communication avenues, and further define the interrelationship between and among these avenues in the context of an event in recent history. Emery Orto, a 6-foot 350-pounds suburban Chicago man, was denied flying with Southwest Airlines from Las Vegas to Midway because of his size (Netter, 2009; eTurboNews Inc., 2010). He was not ready to buy a second ticket nor did he communicate with the Airlines personnel properly so that they could see he was right by letting him board the plane and seeing for themselves (Monson, 2011). After the incident happened, there were a lot of people who were of the point of view that Orto should have been allowed to fly (Texas, 2009). But critically analyzing the situation, one comes to know that the Airlines personnel was only doing its duty by questioning Orto as by boarding him with only one seat booked would not only have made him uncomfortable but the comfort of other passengers sitting next to him was also at stake. The customer of size policy of South West Airlines (2011) states that, â€Å"Customers who are unable to lower both armrests and/or who compromise any portion of adjacent seating should proactively book the number of seats needed prior to travel†. This incident got media’s attention and became a hot topic just because of Orto’s ego and unwillingness to communicate with the Airlines personnel. I believe that Orto should have kept his ego aside. The personnel reports that Orto was offered to board the plane to show that he could fit in one seat without disturbing his seatmates, but he refused which shows irrational behavior and reluctance to